How often can oral transmucosal fentanyl citrate be administered for moderate to severe pain?

Oral transmucosal fentanyl citrate is designed for the management of breakthrough pain, particularly in patients who are already tolerant to opioids. It can be administered every 30 minutes as needed for moderate to severe pain, making it suitable for situations where rapid pain control is necessary. This quick administration schedule is critical for effective pain management in acute scenarios, allowing for timely relief without waiting extended periods.

The other options suggest longer intervals between doses, which would not provide adequate relief for patients experiencing breakthrough pain. Considering that oral transmucosal fentanyl has a relatively fast onset of action, the flexibility to administer it every 30 minutes tailors pain management to the dynamic needs of the patient, especially in a tactical or combat environment where conditions and pain levels can fluctuate rapidly.