TXA is indicated for which of the following conditions?

Tranexamic acid (TXA) is indicated for use in cases of significant blood loss due to trauma, particularly when there is severe bleeding associated with major injuries. It acts as an antifibrinolytic agent, which means it helps to prevent the breakdown of blood clots, thereby promoting hemostasis and potentially reducing the need for blood transfusions. Administering TXA in the early stages of severe hemorrhage can improve survival rates in trauma patients by stabilizing blood clots and minimizing ongoing blood loss.

In the context of the answer provided, option B highlights the critical situation in which TXA is most beneficial — managing significant blood transfusion needs arising from severe bleeding. This is consistent with current guidelines in trauma care, which support the use of TXA in patients who experience serious hemorrhage to enhance their chances of recovery.