What is one of the serious risks of administering NSAIDs such as Motrin in a combat setting?

Administering NSAIDs like Motrin in a combat setting carries the serious risk of increased bleeding. Nonsteroidal anti-inflammatory drugs work by inhibiting certain enzymes (COX-1 and COX-2) that are involved in the production of prostaglandins. Prostaglandins play a crucial role in maintaining the protective lining of the stomach as well as in the clotting process. By inhibiting these enzymes, NSAIDs can compromise platelet function and the integrity of the gastrointestinal system, leading to an increased likelihood of bleeding.

In a combat environment, where traumatic injuries are common and rapid clotting is vital, the use of NSAIDs may exacerbate bleeding from wounds and internal injuries. This makes it essential for combat medics and personnel to consider the potential consequences of NSAID administration, prioritizing the management of bleeding over pain relief whenever necessary.