When should Tranexamic Acid (TXA) NOT be administered after an injury?

Tranexamic Acid (TXA) is an important medication used in the management of trauma-related bleeding. Research indicates that the effectiveness of TXA is most pronounced when administered early after injury. Guidelines dictate that TXA should ideally be given within one hour of injury to maximize its benefits in promoting clot formation and minimizing hemorrhage.

Administering TXA after a certain time frame significantly decreases its efficacy. Specifically, it is generally not recommended to give TXA after 3 hours post-injury because the potential benefits diminish as time progresses. The risk of adverse events or limited effectiveness increases if given significantly later, such as four or six hours after the injury. Therefore, the guideline clearly establishes that TXA should not be administered after 3 hours for optimal outcomes.